PNC-27 (10mg)

PNC-27 Product Description

PNC-27 is a synthetic peptide designed to selectively kill cancer cells by targeting a protein called HDM-2 (also known as MDM2) found on the membranes of many cancer cells. It works by binding to membrane-bound HDM-2, forming pores in the cancer cell membrane, and causing rapid cell death through necrosis, while sparing normal cells.

PNC-27 is derived from the p53 protein’s HDM-2 binding domain (amino acids 12-26) and is linked to a membrane-penetrating sequence, allowing it to enter and act on cancer cell membranes. The peptide binds specifically to HDM-2 present on the surface of cancer cells, not normal cells. This binding leads to the formation of transmembrane pores, disrupting the cell membrane and causing cell lysis and necrosis, independent of the p53 pathway.

PNC-27 Peptide Structure

Molecular Formula: C₁₈₈H₂₉₃N₅₃O₄₄S
Molecular Mass: 4,029.2 g/mol
Synonyms:

• H-PPLSQETFSDLWKLLKKWKMRRNQFWVKVQRG-OH
• PPLSQETFSDLWKLLKKWKMRRNQFWVKVQRG-acid
• H-Pro-Pro-Leu-Ser-Gln-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Le u-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn- Gln-
• Phe-Trp-Val-Lys-Val-Gln-Arg-Gly-OH
• A6, Paralit

Research Areas:

• Anti-Cancer Research