VIP Product Description
Vasoactive Intestinal Peptide (VIP) is a 28-residue neuropeptide with broad endocrine, immune, and neuroprotective actions. Pre-clinical and clinical investigations demonstrate that VIP:
- potently induces vasodilation in systemic and pulmonary circulations via VPAC-mediated cAMP and nitric-oxide pathways, improving hemodynamics in primary pulmonary hypertension patients [1]
- stimulates glucose-dependent insulin secretion through VPAC2 receptor activation on pancreatic β-cells, offering hypoglycemic potential without risk of hypoglycemia [2]
- suppresses pro-inflammatory cytokine (e.g., TNF-α, IL-6) release and shifts T-cell balance toward anti-inflammatory phenotypes, attenuating autoimmune and inflammatory disease activity [3]
- promotes neuronal survival, angiogenesis, and functional recovery after cerebral ischemia, enhancing neurogenesis and reducing infarct volume [4]
- regulates dendritic cell maturation and T-cell differentiation, reinforcing immunological tolerance in models of colitis [5]
- exerts protective effects in cardiopulmonary disorders—ameliorating pulmonary hypertension, asthma, and COPD via combined airway bronchodilation and vascular modulation [6]
Each vial contains 5 mg of lyophilized VIP with no excipients. Reconstitute immediately before use in bacteriostatic water, aliquot single-use doses, and store at ≤ –20 °C to avoid repeated freeze–thaw cycles.
VIP Peptide Structure
Molecular identity
- Core sequence:
H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-Ser-Gly-NH₂ (28 aa) - Peptide formula: C₁₄₇H₂₃₇N₄₃O₄₃S (M_r ≈ 3 326.8 g·mol⁻¹)
- CAS No.: 40077-57-4
Synonyms: VIP; Vasoactive Intestinal Polypeptide; Neuroendocrine hormone VIP
